Synthesis and applicability of partially reduced 2-benzazepines

This review covers recent developments in the area of partially reduced 2-b enzazepines, particularly synthesis and their main applications. The first chapter discusses the principal routes (ring-closure methods with formation of C-N or C-C bonds as well as ring expansion methods) to obtain these het erocycles. The second chapter covers total syntheses of the alkaloids galan thamine, lycoramine, narwedine and clavicipitic acid which all contain the 2-benzazepine core structure. At the end of the chapter, approaches to the homoberbine and ribasine skeleton are given. Additional information is prov ided for synthesis of medicinally important 8,9-dichloro-2,3,4,5tetrahydro- 1H-2-benzazepine.