In the spring of 1999 in rural Newfoundland, abortions in goats were associ
ated with illness in goat workers. An epidemiologic investigation and a ser
ologic survey were conducted in April 1999 to determine the number of infec
tions, nature of illness, and risk factors for infection. Thirty-seven perc
ent of the outbreak cohort had antibody titers to phase II Coxiella burneti
i antigen >1:64, suggesting recent infection. The predominant clinical mani
festation of Q fever was an acute febrile illness. Independent risk factors
for infection included contact with goat placenta, smoking tobacco, and ea
ting cheese made from pasteurized goat milk. This outbreak raises questions
about management of such outbreaks, interprovincial sale and movement of d
omestic ungulates, and the need for discussion between public health practi
tioners and the dairy industry on control of this highly infectious organis
m.