SYNTHESIS OF THE PHOSPHONATE ISOSTERE OF CARBOCYCLIC 5-BROMOVINYLDEOXYURIDINE MONOPHOSPHATE

Authors
COE DM GAROFALO A ROBERTS SM STORER R THORPE AJ
Citation
Dm. Coe et al., SYNTHESIS OF THE PHOSPHONATE ISOSTERE OF CARBOCYCLIC 5-BROMOVINYLDEOXYURIDINE MONOPHOSPHATE, Journal of the Chemical Society. Perkin transactions. I, (21), 1994, pp. 3061-3063
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of the Chemical Society. Perkin transactions. I → ACNP
ISSN journal
0300922X
Issue
21
Year of publication
1994
Pages
3061 - 3063
Database
ISI
SICI code
0300-922X(1994):21<3061:SOTPIO>2.0.ZU;2-H
Abstract
The nucleotide analogue 5 has been synthesized, via formation of the d iet 11, and has been shown to be inactive against HSV in vitro. Resolu tion of the intermediate diol 11 was effected using a highly stereosel ective enzyme-catalysed acetylation.