The effects of supplementation with 19-nor-4-androstene-3,17-dione and 19-nor-4-androstene-3,17-diol on body composition and athletic performance in previously weight-trained male athletes

The purpose of this study was to determine the effects of 8 weeks of norste roid supplementation on body composition and athletic performance in previo usly weight-trained males. Subjects were weight and percent body fat matche d and randomly assigned to receive either 100 mg of 19-nor-4-androstene-3, 17-dione (N-dione) and 56 mg of 19-nor-4-androstene-3, 17-diol (N-diol; 156 mg total norsteroid per day), or a placebo (a multivitamin). Each subject participated in resistance training 4 days/week for the duration of the stu dy. Body composition was assessed via dual-energy X-ray absorptiometry. Cir cumference measures were taken of a relaxed and flexed arm (maximum circumf erence of the arm), waist (level of umbilicus), and thigh (15 cm proximal t o the patella). Strength was determined with a one-repetition maximum bench press, while force and power were determined with a dumbbell bench press ( 60% body weight) on a Stratec Galileo force platform. Profile of mood state s scores were evaluated for vigor and fatigue. There were no significant ch anges in any of the parameters measured. In conclusion, low-dose supplement ation with N-dione and N-diol does not appear to alter body composition, ex ercise performance, or mood states.