p300/CBP/p53 interaction and regulation of the p53 response

Substantial evidence points to a critical role for the p300/CREB binding pr otein (CBP) coactivators in p53 responses to DNA damage. p300/CBP and the a ssociated protein P/CAF bind to and acetylate p53 during the DNA damage res ponse, and are needed for full p53 transactivation as well as downstream p5 3 effects of growth arrest and/or apoptosis. Beyond this simplistic model, p300/CBP appear to be complex integrators of signals that regulate p53, and biochemically, the multipartite p53/p300/CBP interaction is equally comple x. Through physical interaction with p53, p300/CBP can both positively and negatively regulate p53 transactivation, as well as p53 protein turnover de pending on cellular context and environmental stimuli, such as DNA damage.