CP2289, A NEW 5-HT3 RECEPTOR-LIGAND - AGONISTIC ACTIVITIES ON GASTROENTERIC MOTILITY

Authors
SATO Y IMAI M AMANO K IWAMATSU K KONNO F KURATA Y SAKAKIBARA S HACHISU M IZUMI M MATSUKI N SAITO H
Citation
Y. Sato et al., CP2289, A NEW 5-HT3 RECEPTOR-LIGAND - AGONISTIC ACTIVITIES ON GASTROENTERIC MOTILITY, Biological & pharmaceutical bulletin, 20(7), 1997, pp. 752-755
Citations number
23
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Biological & pharmaceutical bulletin → ACNP
ISSN journal
09186158
Volume
20
Issue
7
Year of publication
1997
Pages
752 - 755
Database
ISI
SICI code
0918-6158(1997)20:7<752:CAN5R->2.0.ZU;2-V
Abstract
A new 5-HT3 receptor ligand, CP2289, was synthesized and pharmacologic ally tested. Although CP2289 inhibited the Bezold-Jarisch reflex, it c ontracted the excised ileal muscle of mice, rats and guinea pigs. This response may reheat a partial agonist character of CP2289 in the gut. In vivo antiemetic and gastric emptying tests gave similar results.