THE EFFECTS OF CRUDE POLYSACCHARIDE FRACTIONS OF 4 KINDS OF KAMPO-HOZAI ADMINISTERED ORALLY ON NITRIC-OXIDE PRODUCTION BY MURINE PERITONEAL-MACROPHAGES

Authors
TERAWAKI K NOSE M OGIHARA Y
Citation
K. Terawaki et al., THE EFFECTS OF CRUDE POLYSACCHARIDE FRACTIONS OF 4 KINDS OF KAMPO-HOZAI ADMINISTERED ORALLY ON NITRIC-OXIDE PRODUCTION BY MURINE PERITONEAL-MACROPHAGES, Biological & pharmaceutical bulletin, 20(7), 1997, pp. 809-811
Citations number
16
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Biological & pharmaceutical bulletin → ACNP
ISSN journal
09186158
Volume
20
Issue
7
Year of publication
1997
Pages
809 - 811
Database
ISI
SICI code
0918-6158(1997)20:7<809:TEOCPF>2.0.ZU;2-F
Abstract
In order to characterize the pharmacological role of the crude polysac charide fraction in kampo-hozai, we chose 4 kinds of kampo-hozai, Shos aiko-to, Daisaiko-to, Hachimi-jio-gan and Hochu-ekki-to, and studied t he effects of their crude polysaccharide fractions on nitric oxide (NO ) production by 3% thioglycollate-induced murine peritoneal macrophage . Oral administration of these fractions for 7 d augmented lipopolysac charide (LPS, 0.1-10 mu g/ml)-induced NO production by peritoneal macr ophages. These results suggest the possibility that a crude polysaccha ride fraction affect the macrophage function in most kampo-hozai.