Pj. Kowalski et Afg. Paulino, Proliferation index as a prognostic marker in hemangiopericytoma of the head and neck, HEAD NECK, 23(6), 2001, pp. 492-496
Citations number
18
Categorie Soggetti
Otolaryngology
Journal title
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
Background. Hemangiopericytoma (HPC) of the head and neck is a rare neoplas
m whose biologic behavior is difficult to predict by means of conventional
histologic parameters.
Methods. H & E-stained sections from 12 cases of HPC were reviewed. Prolife
ration index was assessed using an immunoperoxidase stain for MIB-1 (Ki-67)
.
Results. The study group consisted of 4 adult men, 5 adult women, and I inf
ant male. Necrosis, hypercellularity, and pleomorphism were found in 1, 5,
and 6 case(s), respectively. The mitotic index per 10 high power fields var
ied from 0-1 to 15. Proliferation indices using MIB-1 ranged from 2.6% to 5
2.5%. Clinical follow-up revealed 3 cases with recurrence all possessing pr
oliferation indices of approximately 10%.
Conclusions. Standard histomorphologic features may be inadequate predictor
s of clinical outcome. A proliferation index of 10% or greater may indicate
a more aggressive subset of HPC of the head and neck. (C) 2001 John Wiley
& Sons, Inc.