CYCLIC DIPEPTIDES WITH 1-AMINOCYCLOPROPANE-1-CARBOXYLIC ACID

Authors
KASAFIREK E MOURAL J VINSOVA J STURC A TAIMR J
Citation
E. Kasafirek et al., CYCLIC DIPEPTIDES WITH 1-AMINOCYCLOPROPANE-1-CARBOXYLIC ACID, Collection of Czechoslovak Chemical Communications, 62(6), 1997, pp. 941-947
Citations number
7
Categorie Soggetti
Chemistry
Journal title
Collection of Czechoslovak Chemical Communications → ACNP
ISSN journal
00100765
Volume
62
Issue
6
Year of publication
1997
Pages
941 - 947
Database
ISI
SICI code
0010-0765(1997)62:6<941:CDW1A>2.0.ZU;2-Q
Abstract
Cyclic dipeptides of the formula cyclo(-Acc-X-), where Acc = 1-aminocy clopropane-1-carboxylic acid, X = Gly, Ala, Val, Leu, Phe or Tyr, were synthesized. The prepared 2,5-piperazinediones showed no proliferativ e or antiproliferative activity on normal human embryo cells as well a s on HL60 leukemia cells. Results of trace memory assays in mice were negative.