The relationship between HA-1 compatability and the activation of helper Tlymphocyte precursors

The relationship between che compatibility in minor histocompatibility HA-1 antigen and the activation of helper (IL-2 producing) T lymphocyte precurs ors in vine was studied in the group of 17 HLA-A2 positive HLA identical si blings. Although the number of pairs studied is still small, no correlation has been found between HA-1 compatibility and helper T lymphocyte precurso rs activation. The results presented here could suggest the possibility tha t the HTLp assay does not have to be a relevant parameter for the detection of HA-l mismatches in HLA identical siblings.