Synthesis of some modified guanosine derivatives having substitution at 8-p
osition by some amino compounds such as diphenylamine, ethyl hydrazinoforma
te, serine, proline and glycine have been described. Furthermore, 2',3'-O-i
sopopylidene-8-bromoguanosine reacts with dimethylamine to give 2',3'-O-iso
popylidene-8-(N,N-dimethyl)aminoguanosine. The later compound is used for t
he synthesis of 2,5'-anhydronucleoside. The cyclonucleoside is treated with
H2S in dry pyridine to give 5'-thioguanosine derivative 11. The biological
activity of the synthesized compounds has also been measured.