DNA cleavage by photogenerated Rh-2(O2CCH3)(4)(H2O)(2)(+)

Authors
Fu, PKL Bradley, PM Turro, C
Citation
Pkl. Fu et al., DNA cleavage by photogenerated Rh-2(O2CCH3)(4)(H2O)(2)(+), INORG CHEM, 40(11), 2001, pp. 2476
Citations number
25
Categorie Soggetti
Inorganic & Nuclear Chemistry
Journal title
INORGANIC CHEMISTRY
ISSN journal
00201669 → ACNP
Volume
40
Issue
11
Year of publication
2001
Database
ISI
SICI code
0020-1669(20010521)40:11<2476:DCBPR>2.0.ZU;2-8
Abstract
Irradiation of Rh-2(O2CCH3)(4)(H2O)(2) with visible light in the presence o f electron accepters results in the formation of the oxidized complex, Rh-2 (O2CCH3)(4)- (H2O)(2)(+). Photogenerated Rh-2(O2CCH3)(4)(H2O)(2)(+) is able to cleave plasmid DNA, whereas the Rh-2(O2CCH3)(4)(L)(2)(+) complexes with nonlabile axial ligands, L, such as py (pyridine) and PPh3 (triphenylphosp hine), do not cleave the double helix. Rh-2(O2CCH3)(4)(H2O)(2)(+) [GRAPHICS]