MACROCYCLIZATION ON SOLID SUPPORT USING HECK REACTION

Authors
AKAJI K KISO Y
Citation
K. Akaji et Y. Kiso, MACROCYCLIZATION ON SOLID SUPPORT USING HECK REACTION, Tetrahedron letters, 38(29), 1997, pp. 5185-5188
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
29
Year of publication
1997
Pages
5185 - 5188
Database
ISI
SICI code
0040-4039(1997)38:29<5185:MOSSUH>2.0.ZU;2-0
Abstract
A novel intramolecular macrocyclization reaction on solid support usin g Heck reaction was achieved. The Heck coupling of acrylic acid amide to 3-iodobenzylamine on solid support proceeds smoothly to yield a cyc lic tetrapeptide derivative containing a new 3-substituted cinnamic ac id template and Arg-Gly-Asp sequence. The macrocyclization reaction ta kes place more rapidly on solid support than in solution. (C) 1997 Els evier Science Ltd.