In recent years there has been considerable interest in the effect of disor
der on the nature and universality of wetting transitions. One of the most
frequently studied systems is that in which geometrical disorder is present
in the form of substrate roughness. In 2D there is compelling evidence tha
t the critical wetting transition found for a flat substrate may become fir
st order when surface roughness is included. In particular. if the roughnes
s exponent of the wall exceeds the anisotropy index of interface fluctuatio
ns in the bulk, then first-order wetting is found. Here we extend the inves
tigation of roughness-induced effects: to the situation in which we have un
binding of two fluctuating interfaces characterized by different roughness
exponents zeta (1) and zeta (2) (e.g., a fluid membrane depinning from a li
quid-vapor interface) in the absence of quenched disorder. In this case sym
metry prevents a change in order of the unbinding transition as the roughne
sses are varied; however, the critical behavior is again found to be contro
lled by the larger of zeta (1) and zeta (2). In addition, our results depen
d quantitatively on a nonuniversal parameter related to the relative curvat
ure of the two interfaces whenever zeta (1) not equal zeta (2).