An open trial of plant-source derived phosphatydilserine for treatment of age-related cognitive decline

We assessed whether the efficacy of plant-source derived phosphatydilserine tone of the phospholipids which play an important functional role in membr ane-related processes in the brain) for treatment of age related cognitive decline is consistent with previous (placebo controlled) positive findings with bovine derivative of PS (BC-PS). Eighteen healthy elderly volunteers m eeting Age Associated Memory Impairment inclusion and exclusion criteria we re treated for 12 weeks with plant-source derived phosphatydilserine (PS) ( 100 mg x 3/day P.O.) and evaluated at base line, after 6 weeks of treatment and at the end of the trial. Fifteen concluded the study. All but two outc ome measures elicited a significant drug over time effect. Post-hoc paired t-tests showed that the significant effect was attributable to an improveme nt from base line to week 6 and that effect was maintained at week 12. Thes e results are encouraging. However, they await double-blind controlled veri fication in a large sample before suggesting that this may be a viable appr oach to the treatment of age-related cognitive decline, without exposing th e patients to possible hazards involved in the treatment with bovine deriva tive of PS (BC-PS).