Postprandial hyperlipidemia in Zucker diabetic fatty fa/fa rats, an animalmodel of type II diabetes, and its amelioration by acyl-CoA : cholesterol acyltransferase inhibition

Authors
Fujinami, K Kojima, K Aragane, K Kusunoki, J
Citation
K. Fujinami et al., Postprandial hyperlipidemia in Zucker diabetic fatty fa/fa rats, an animalmodel of type II diabetes, and its amelioration by acyl-CoA : cholesterol acyltransferase inhibition, JPN J PHARM, 86(1), 2001, pp. 127-129
Citations number
10
Categorie Soggetti
Pharmacology & Toxicology
Journal title
JAPANESE JOURNAL OF PHARMACOLOGY
ISSN journal
00215198 → ACNP
Volume
86
Issue
1
Year of publication
2001
Pages
127 - 129
Database
ISI
SICI code
0021-5198(200105)86:1<127:PHIZDF>2.0.ZU;2-K
Abstract
PostprandiaI hyperlipidemia (PH) is frequently observed in diabetic patient s. We performed an oral fat-loading test in Zucker diabetic fatty (ZDF) fa/ fa rats, a model for type II diabetes, to determine whether PI-I was induce d in the rats. Post fat-loading changes in serum cholesterol and triglyceri de levels were significantly greater in the fa/fa rats than those seen in t heir lean littermates and an acyl-CoA:cholesterol acyltransferase (ACAT) in hibitor significantly reduced these levels by 24% and 31%, respectively. Th erefore, we confirmed that PH appeared in ZDF fa/fa rats by fat loading and ACAT inhibition may be a potential treatment for PH.