Glycemic response to a food starch esterified by 1-octenyl succinic anhydride in humans

To evaluate the glycemic response to a food starch esterified by 1-octenyl succinic anhydride (OSA), 30 healthy nondiabetic adult subjects were studie d in a double-blind crossover design. After an overnight fast, subjects con sumed a product containing either 25 g of glucose or 25 g of OSA-substitute d starch. Finger-prick capillary blood was obtained at baseline and 15, 30, 45, 60, 90, and 120 min postprandial for glucose measurement. After OSA tr eatment, the rise in blood glucose was reduced(P < 0.05) at 15 and 30 min a nd tended (P < 0.08) to be lower at 45 min. Mean peak rise in glucose was r educed 19% (P <less than> 0.01) by OSA (3.30 +/- 0.19 versus 2.66 +/- 0.16 mmol/L) compared to glucose, but time to peak did not differ between treatm ents. Net incremental area under the curve was also lower (P < 0.05) on OSA compared to glucose. Minimal effects on gastrointestinal symptoms (intensi ty and frequency of nausea, cramping, distention, and flatulence) were note d for both products, with no clinically significant difference between prod ucts. In conclusion, starch substitution with OSA attenuated the postprandi al glycemic excursion compared to an equivalent glucose challenge and was w ell tolerated by fasting healthy adult subjects.