Biotransformation of selamectin with Streptomyces lydicus SX-1298 using a novel static agar fermentation system with Reemay (R) mesh

Authors
Pacey, MS Barnes, MM Monday, RA Ritzau, M Wellington, EMH
Citation
Ms. Pacey et al., Biotransformation of selamectin with Streptomyces lydicus SX-1298 using a novel static agar fermentation system with Reemay (R) mesh, J ANTIBIOT, 54(5), 2001, pp. 448-454
Citations number
7
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF ANTIBIOTICS
ISSN journal
00218820 → ACNP
Volume
54
Issue
5
Year of publication
2001
Pages
448 - 454
Database
ISI
SICI code
0021-8820(200105)54:5<448:BOSWSL>2.0.ZU;2-Q
Abstract
A novel approach to biotransformation is described using a solid medium mat rix and Reemay (R) mesh that gives efficient biotransformation of compounds with minimal matrices in the ensuing gum solids. Using this approach with a newly isolated biotransforming organism, Streptomyces lydicus SX1298, a s eries of hydroxylations and an O-demethylation is described for selamectin the first endectocide for cats and dogs.