Cyclodextrin - A carrier or synthon? Synthesis of per-o-methyl-beta-cyclodextrin-GM(3)

Authors
Haque, W Diakur, J
Citation
W. Haque et J. Diakur, Cyclodextrin - A carrier or synthon? Synthesis of per-o-methyl-beta-cyclodextrin-GM(3), J CARB CHEM, 20(1), 2001, pp. 17-29
Citations number
18
Categorie Soggetti
Chemistry & Analysis
Journal title
JOURNAL OF CARBOHYDRATE CHEMISTRY
ISSN journal
07328303 → ACNP
Volume
20
Issue
1
Year of publication
2001
Pages
17 - 29
Database
ISI
SICI code
0732-8303(2001)20:1<17:C-ACOS>2.0.ZU;2-J
Abstract
Cyclodextrins are currently under investigation for their utility as drug d elivery agents. One property of the parent cyclic oligosaccharides which re quires further modification for advanced drug delivery applications is that of site-directing capability. We have utilized beta -cyclodextrin as a sta rting material for the synthesis of the GM(3) trisaccharide and have conjug ated this targeting ligand to a derivative of the parent beta -cyclodextrin . Synthesis of this cyclodextrin derivative, namely 18, is presented.