Retention-property relationships of anticonvulsant drugs by biopartitioning micellar chromatography

Epilepsy may be considered as a group of disorders with only one thing in c ommon: the fact that recurrent anomalous electrochemical phenomena appear i n the central nervous system. Different classes of drugs are included under the generic term of anticonvulsant drugs. All of them work by decreasing d ischarge propagation in different ways. Biopartitioning micellar chromatogr aphy (BMC) is a mode of reversed-phase liquid chromatography, which can be used as an in vitro system to model the biopartitioning process of drugs wh en there are no active processes. In this paper, relationships between the BMC retention data of anticonvulsant drugs, their pharmacokinetics (oral ab sorption, protein binding, volume of distribution, clearance, and renal eli mination) and their therapeutic parameters (therapeutic, toxic and comatose -fatal concentration, and LD,,) are studied and the predictive ability of m odels is evaluated. (C) 2001 Elsevier Science B.V. All rights reserved.