A pilot study assessing the impact of heat on the transdermal delivery of testosterone

Citation
Ts. Shomaker et al., A pilot study assessing the impact of heat on the transdermal delivery of testosterone, J CLIN PHAR, 41(6), 2001, pp. 677-682
Citations number
20
Categorie Soggetti
Pharmacology,"Pharmacology & Toxicology
Journal title
JOURNAL OF CLINICAL PHARMACOLOGY
ISSN journal
00912700 → ACNP
Volume
41
Issue
6
Year of publication
2001
Pages
677 - 682
Database
ISI
SICI code
0091-2700(200106)41:6<677:APSATI>2.0.ZU;2-Y
Abstract
This study evaluated the effect of locally applied heat on the transdermal delivery of testosterone. Six healthy adult volunteers were tested three ti mes while receiving a 5 mg androgen patch, the same patch with a heat-gener ating patch, and no patch at oil over 12 hours. Statistically significant d ifferences in mean maximum serum testosterone concentration values were see n. Heat plus patch resulted in a mean maximum serum testosterone concentrat ion of 939 ng/dl versus 635 ng/dl (patch only) and 425 ng/dl (no patch). (H eat + patch vs, no patch: p < 0.001; heat + patch vs. patch :p < 0. 001; pa tch vs. no patch:p = 0.003.) The area under the curve of plasma testosteron e concentration versus time values were means of 4114 ng/dl(.)h versus 1985 ng/dl(.)hfor the patch-only group (p 0.001). The use of heat improved abso rption of transdermal testosterone and decreased time to peak serum testost erone concentrations, resulting in a statistically significant difference i n mean maximum serum testosterone concentrations compared with the use of t he patch without heat.