DYNAMIC SCINTIGRAPHY OF BONE AND BONE-MARROW IN MULTIPLE-MYELOMA PATIENTS WITH BONE-MARROW TRANSPLANTS

Purpose: To determine whether dynamic registration at bone and bone-ma rrow scintigraphy produces additional information compared to subseque nt static registrations of bone-marrow transplants in multiple myeloma patients. Material and Methods: In a prospective study, 8 dynamic bon e and 6 dynamic bone-marrow scintigraphies were performed in 10 patien ts. The dynamic scintigraphies were compared with conventional radiogr aphy, MR images, and static scintigraphies of bone and bone marrow. Re sults: No additional information was revealed by the dynamic registrat ion method; on the contrary, 4 of the 8 known lesions were not discern ed at dynamic registration. An incidental observation was that the tim e-activity curves of both radiopharmaceuticals had a specific pattern. Conclusion: Dynamic registration at bone and bone-marrow scintigraphy was not useful for detecting disease in multiple myeloma lesions.