Cytotoxic constituents of the fruits of Cananga odorata

A new guaipyridine sesquiterpene alkaloid, cananodine (1), and two new eude smane sesquiterpines, cryptomeridiol 11-alpha -L-rhamnoside (2) and gamma - eudesmol 11-alpha -L-rhamnoside (3), along with gamma -eudesmol (4), were i solated from the fruits of Cananga odorata. The structures of compounds 1-3 were established on the basis of NMR and MS methods. In addition, compound s 1-4 and four previously reported alkaloids, cleistopholine (5), N-trans-f eruloyltyramine (8), (+)-ushinsunine-beta -N-oxide (7), and lyscamine (8), were evaluated for cytotoxicity against two human hepatocarcinoma cell line s.