Naphthopyranone glycosides from Paepalanthus microphyllus

Three new naphthopyranone glycosides, paepalantine-9-O-beta -D-glucopyranos yl-(1 -->6)-beta -D-glucopyranoside (I), paepalantine-9-O-alpha -L-arabinop yranosyl-(1 -->6)-beta -D-glucopyranoside (2), and paepalantinc-9-O-alpha - L-rhamnopyranosyl-( (1 -->6)-beta -D-glucopyranoside (3), along with the kn own paepalantine-9-O-beta -D-glucopyranoside (4) were isolated from aerial parts of Paepalanthus microphyllus. These compounds were characterized by s pectrometric methods, including electrospray mass spectrometry and 1D and 2 D NMR experiments. As a part of our program for screening natural compounds for anti-HIV activity, compounds 1-4 were tested in C8166 cells infected w ith HIV 1(MN).