Use of polymer-supported dialkylphosphinobiphenyl ligands for palladium-catalyzed amination and Suzuki reactions

Authors
Parrish, CA Buchwald, SL
Citation
Ca. Parrish et Sl. Buchwald, Use of polymer-supported dialkylphosphinobiphenyl ligands for palladium-catalyzed amination and Suzuki reactions, J ORG CHEM, 66(11), 2001, pp. 3820-3827
Citations number
50
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
JOURNAL OF ORGANIC CHEMISTRY
ISSN journal
00223263 → ACNP
Volume
66
Issue
11
Year of publication
2001
Pages
3820 - 3827
Database
ISI
SICI code
0022-3263(20010601)66:11<3820:UOPDLF>2.0.ZU;2-A
Abstract
The preparations of polymer-supported dialkylphosphinobiphenyl ligands (3) are reported. A palladium catalyst based on ligand 3a is active for aminati on and Suzuki reactions using unactivated aryl iodides, bromides, or chlori des. Filtration of the catalyst from the reaction mixture allows for simpli fied product isolation via an aqueous workup. The resin-bound catalyst can be recycled without additional palladium in both the amination and Suzuki r eactions.