Elastic bounded diffusion and electron propagation: Dynamics of the wiringof a self-assembly of immunoglobulins bearing terminally attached ferrocene poly(ethylene glycol) chains according to a spatially controlled organization

Authors
Anne, A Demaille, C Moiroux, J
Citation
A. Anne et al., Elastic bounded diffusion and electron propagation: Dynamics of the wiringof a self-assembly of immunoglobulins bearing terminally attached ferrocene poly(ethylene glycol) chains according to a spatially controlled organization, J AM CHEM S, 123(20), 2001, pp. 4817-4825
Citations number
37
Categorie Soggetti
Chemistry & Analysis",Chemistry
Journal title
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
ISSN journal
00027863 → ACNP
Volume
123
Issue
20
Year of publication
2001
Pages
4817 - 4825
Database
ISI
SICI code
0002-7863(20010523)123:20<4817:EBDAEP>2.0.ZU;2-Y
Abstract
Molecular monolayers of immunoglobulins bearing terminally attached ferroce ne poly(ethylene glycol) chains (IgG-PEG-Fc) were self-assembled at an elec trode surface in a step-by-step manner involving antigen-antibody recogniti on reactions. The total number N of assembled IgG-PEG-Fc monolayers and the number of spacers ni separating two successive IgG-PEG-Fc monolayers were controlled and varied. Electron transport through the protein assembly invo lves the dynamics of the terminally attached PEG chains and isotopic electr on exchange between ferrocene heads belonging to successive IgG-PEG-Fc mono layers. The model of elastic bounded diffusion enabled us to analyze quanti tatively the dependence of the rate of electron transport on N, n(i), and t he rate constant (k(e)) of isotopic electron exchange. Wiring of a molecula r monolayer of redox enzyme is also quantitatively characterized.