Pm. Galenko et Nn. Nedopitanskaya, COMBINED EFFECT OF CARCINOGENIC N-NITROSO DIMETHYLAMINE PRECURSORS AND FRACTIONED GAMMA-IRRADIATION ON TUMOR-DEVELOPMENT IN RATS, Eksperimental'naa onkologia, 19(2), 1997, pp. 110-117
The influence of combined action of N-nitrosodimethylamine (NDMA) and
fractioned gamma-irradiation on tumor development in rats was investig
ated, Both the tumor frequency and tumor plurality coefficient Rave be
en studied for two types of treatment: precursors of NDMA (amidopyrine
and/or sodium nitrite (SN)) alone and the combination ''precursors pl
us radiation''. Tumor frequency decreased by about 11% after combinati
on of gamma-irradiation and precursors in comparison with precursors a
lone. Nevertheless, treatment with SN and gamma-irradiation did not ch
ange tumor frequency in comparison with SN alone. irradiation of rats
treated with precursors led to an increased tumor plurality coefficien
t.