ANTITUMOR PROPERTIES OF MODIFIED RECOMBIN ANT HUMAN LYMPHOTOXIN IN-VIVO

Authors
DENISOV AA LYUBIMOV II NIKOLAYEVA OG
Citation
Aa. Denisov et al., ANTITUMOR PROPERTIES OF MODIFIED RECOMBIN ANT HUMAN LYMPHOTOXIN IN-VIVO, Eksperimental'naa onkologia, 19(2), 1997, pp. 138-142
Citations number
18
Categorie Soggetti
Oncology
Journal title
Eksperimental'naa onkologia → ACNP
ISSN journal
02043564
Volume
19
Issue
2
Year of publication
1997
Pages
138 - 142
Database
ISI
SICI code
0204-3564(1997)19:2<138:APOMRA>2.0.ZU;2-M
Abstract
Antitumor properties of modified recombinant human lymphotoxin (rLT) i n murine models of fibrosarcoma MC-11 and melanoma B-16 were studied. Maximal antitumor effect was observed after intratumoral and intraperi toneal injections of rLT for 5 (fibrosarcoma MC-11) and 7 (melanoma B- 16) days at the doses of 10(3) and 10(4) U/mice, respectively. Specifi c immunoglobulin G to pure rLT was found to neutralize completely the cytotoxicity in vitro and the antitumor activity of rLT in vivo. The p reparation showed an activity against well established tumors and had no effect on immature tumors.