OXYGEN-ACTIVATING ABILITY OF NEUTROPHILS FROM CHILDREN WITH NON-HODGKINS-LYMPHOMAS IN THE THERAPY WITH G-CSF

Neutrophils' capability to generate active oxygen forms is supposed to play a key role in the development of response of the host defence sy stem. This activity of neutrophils has not been investigated in the pa tients with lymphomas at neutropenia and in the course of therapy of p atients. By a method of luminol-dependent chemiluminescence, the abili ty of neutrophils to generate active oxygen forms under adhesion of ce lls on glass or action of latex particles, phytohemagglutinin and arac hidonic acid was shown to be reduced in children with non-Hodgkin's ly mphomas after intensive chemotherapy in conditions of neutropenia in c omparison with healthy donors. The use of the granulocyte colony-stimu lating factor G-CSF for the induction of granulocytopoiesis in patient s with non-Hodgkin's lymphomas results in simultaneous stimulation of leukopoiesis and increased functional activity of cells, suggested by the increase in the yield of active oxygen forms under the activation of neutrophils.