R. Hovland et al., Gadolinium DO3A derivatives mimicking phospholipids; preparation and in vitro evaluation as pH responsive MRI contrast agents, J CHEM S P2, (6), 2001, pp. 929-933
Citations number
11
Categorie Soggetti
Physical Chemistry/Chemical Physics
Journal title
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2
A series of Gd-DO3A derivatives (8a-d) mimicking phospholipids have been pr
epared. Two of the complexes, Gd-HADB-DO3A (8a) and Gd-HADO-DO3A (8b), have
been evaluated as pH responsive MRI contrast agents in vitro. The T-1-rela
xivity (r(1)) of Gd-HADO-DO3A (8b) increased 142% on changing the pH from 6
to 8. The pH dependence is thought to arise from the formation of supramol
ecular structures caused by deprotonation of the amphiphilic complex at alk
aline pH.