Pharmacokinetic behaviour of phenylglyoxal bis(guanylhydrazone) (PGBG) after intravenous administration in rabbits

Phenylglyoxal bis(guanylhydrazone) (PGBG) is a synthesized analogue of meth ylglyoxal bis(guanylhydrazone) (MGBG), which has demonstrated anti-parasiti c activity in rabbits. The pharmacokinetic behavior of PGBG after intraveno us administration (10 mg/kg bodyweight) was studied in five rabbits. Plasma concentrations of PGBG were measured by high-performance liquid chromatogr aphy. Plasma PGBG concentrations decreased rapidly and were not detectable beyond 90 min after treatment. The mean [+/- standard deviation (SD)] volum e of distribution at steady state (Vdss) was 2.19 +/- 0.47 l/kg and the mea n plasma clearance value (CI) was 29.99 +/- 3.98 ml/min kg. This drug is ra pidly climinated from the body in rabbits, having a short elimination half- life (0.93 h) and mean residence time (1.21 h).