There has been considerable changes in cancer epidemiology during the last
fifteen years because of the discovery of numerous cancer susceptibility ge
nes. Knowledge of environmental factors, such as radiation, nutrition, or c
hemical carcinogens, which have been evidenced during the last century, con
tinues to regularly improve. Nowadays, there is a general agreement on the
respective contribution of genetic and environmental factors in causing can
cer. Efforts are now concentrating on improving the knowledge of the joint
effects of these different factors. This will help defining prevention poli
cy, in particular towards subgroups of specifically sensitive individuals.
However, the definition of such a policy is expected to encounter a number
of difficulties in the future.