Magnetic resonance microscopy of morphological alterations in mouse trabecular bone structure under conditions of simulated microgravity

Authors
Gardner, JR Hess, CP Webb, AG Tsika, RW Dawson, MJ Gulani, V
Citation
Jr. Gardner et al., Magnetic resonance microscopy of morphological alterations in mouse trabecular bone structure under conditions of simulated microgravity, MAGN RES M, 45(6), 2001, pp. 1122-1125
Citations number
20
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging","Medical Research Diagnosis & Treatment
Journal title
MAGNETIC RESONANCE IN MEDICINE
ISSN journal
07403194 → ACNP
Volume
45
Issue
6
Year of publication
2001
Pages
1122 - 1125
Database
ISI
SICI code
0740-3194(200106)45:6<1122:MRMOMA>2.0.ZU;2-2
Abstract
This work describes the use of magnetic resonance (MR) microscopy to examin e changes in tibial trabecular bone structure in mice following 28 days of hindlimb suspension, a model simulating the effects of microgravity in rode nts. In this first MR study involving mice, analysis of 3D images showed th at apparent bone volume fraction, trabecular number, and trabecular thickne ss were decreased, and apparent trabecular spacing increased, significantly (P < 0.05) in hindlimb-suspended mice compared to controls. These changes agreed well with light microcopy measurements from an independent study and also with actual spaceflight experiments with rats. (C) 2001 Wiley-Liss, I nc.