One week pulse therapy with itraconazole (200 mg day(-1)) for onychomycosis. Evaluation of treatment results according to patient background

We investigated background factors of patients that affect the response of onycomycosis to pulse therapy with itraconazole. The regimen used in this s tudy involved administering 200 mg of itraconazole orally on a daily basis for 1 week as one pulse, which is half of the normally recommended dose. Th e number of pulses was fixed at one per month, and altered in accordance wi th improvements in the infected nails and/or the patients' request. Patient background (n=63) including sex, age, occupation, duration of the disease, site of lesion (fingernail, toenail), number of affected nails, clinical t ypes, severity of thickening, presence or absence of pathogens, the presenc e or absence of underlying diseases such as adult onset diseases, turbidity of the target nails before therapy and the number and duration of pulses w as investigated. The efficacy of the therapy was evaluated after 12 months. A complete cure was judged to have taken place if an entirely healthy nail plate re-grew in place of the diseased nail, whereas lack of success was d efined as the persistence of lesions beyond the designated time period. The average number and duration of pulses were 4.7 +/-3.2 times over 5.6 +/-4. 3 months, respectively. The rate of complete cure was 62%. Factors in the p atients' background that were judged to have an influence on treatment resu lts were the relative duration of the disease, the number of affected nails , and severity of thickening. With regard to the efficacy of the therapy in terms of the number and duration of pulses, 78% of 23 patients who were gi ven pulse therapy two to six times during a course of 2 to 6 months achieve d total cure.