Association analysis of NOTCH4 loci in schizophrenia using family and population-based controls

Authors
Sklar, P Schwab, SG Williams, NM Daly, M Schaffner, S Maier, W Albus, M Trixler, M Eichhammer, P Lerer, B Hallmayer, J Norton, N Williams, H Zammit, S Cardno, AG Jones, S McCarthy, G Milanova, V Kirov, G O'Donovan, MC Lander, ES Owen, MJ Wildenauer, DB
Citation
P. Sklar et al., Association analysis of NOTCH4 loci in schizophrenia using family and population-based controls, NAT GENET, 28(2), 2001, pp. 126-128
Citations number
5
Categorie Soggetti
Molecular Biology & Genetics
Journal title
NATURE GENETICS
ISSN journal
10614036 → ACNP
Volume
28
Issue
2
Year of publication
2001
Pages
126 - 128
Database
ISI
SICI code
1061-4036(200106)28:2<126:AAONLI>2.0.ZU;2-R
Abstract
A genetic association between NOTCH4 and schizophrenia has previously been proposed(1). Unsing all markers previously shown to be associated, we found no evidence for such in three independent family-based samples (n=519 pare nt-offspring trios), and a case-control sample derived from the same ethnic background as the original observaton, These data strongly suggest that NO TCH4 is not a significant susceptibility allele for schizophrenia.