Mitotic recombination is suppressed by chromosomal divergence in hybrids of distantly related mouse strains

Citation
Cs. Shao et al., Mitotic recombination is suppressed by chromosomal divergence in hybrids of distantly related mouse strains, NAT GENET, 28(2), 2001, pp. 169-172
Citations number
24
Categorie Soggetti
Molecular Biology & Genetics
Journal title
NATURE GENETICS
ISSN journal
10614036 → ACNP
Volume
28
Issue
2
Year of publication
2001
Pages
169 - 172
Database
ISI
SICI code
1061-4036(200106)28:2<169:MRISBC>2.0.ZU;2-5
Abstract
Mitotic recombination occurs with high frequency in humans(1,2) and mice(3) . It leads to loss of heterozygosity (LOH) at important gene loci and can c ause disease(4-7). However, the genetic modulators of mitotic recombination are not well understood. As recombination depends on a high level of nucle otide sequence homology(8-12), we postulate that the frequency of somatic v ariants derived from mitotic recombination should be diminished in progeny from crosses between strains of mice in which nucleotide sequences have div erged. Here we report that mitotic recombination is suppressed, to various degrees in different tissues, in hybrids of distantly related mouse strains . Reintroduction of greater chromosomal homology by backcrossing restores m itotic recombination in offspring. Thus, chromosomal divergence inhibits mi totic recombination and, consequently, may act as a modifier of cancer susc eptibility by limiting the rate of LOH. The suppression of mitotic recombin ation in some F-1 hybrids in which meiotic recombination persists indicates that these processes are differentially affected by chromosomal divergence .