Deconstructing the LDL receptor - a rhapsody in pieces

Authors
Herz, J
Citation
J. Herz, Deconstructing the LDL receptor - a rhapsody in pieces, NAT ST BIOL, 8(6), 2001, pp. 476-478
Citations number
14
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NATURE STRUCTURAL BIOLOGY
ISSN journal
10728368 → ACNP
Volume
8
Issue
6
Year of publication
2001
Pages
476 - 478
Database
ISI
SICI code
1072-8368(200106)8:6<476:DTLR-A>2.0.ZU;2-1
Abstract
The LDL receptor plays a central role in the control of plasma cholesterol levels and the prevention of coronary artery disease. Recent studies now sh ed light on the structural organization of several independently folded mod ules and domains from which the receptor is assembled, providing substantia l insights into the mechanics of receptor function and the consequences of disease causing mutations.