The procedure to calculate masses and matrix-elements in the presence of mi
xing of the basis states is explained in detail. We then apply this procedu
re to the two-loop calculation in Chiral Perturbation Theory of pseudoscala
r masses and decay constants including quark mass isospin breaking. These r
esults are used to update our analysis of K-l4 done previously and obtain a
value of m(u)/m(d) in addition to values for the low-energy-constants L-i(
r). (C) 2001 Published by Elsevier Science B.V.