An efficient synthesis of mimetics of neamine for RNA recognition

Authors
Ding, YL Hofstadler, SA Swayze, EE Griffey, RH
Citation
Yl. Ding et al., An efficient synthesis of mimetics of neamine for RNA recognition, ORG LETT, 3(11), 2001, pp. 1621-1623
Citations number
19
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
3
Issue
11
Year of publication
2001
Pages
1621 - 1623
Database
ISI
SICI code
1523-7060(20010531)3:11<1621:AESOMO>2.0.ZU;2-3
Abstract
[GRAPHICS] As mimetics of neamine, several 4-heterocyclic 2-deoxystreptamine derivativ es were chemically synthesized for RNA recognition. Conversion of 4-methylt hiomethyl-5,6-di-O-acetyl-diazido-2-deoxystreptamine to the 4-chloromethyl derivative followed by reactions with different nuclophilic reagents gave t he 4-heterocyclic 2-deoxystreptamine derivatives in satisfactory yields.