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Recent efforts in our laboratories have resulted in a synthetic approach to
ward C2'-alkylated K252a analogues via extension of a K252a cyclofuranosyla
tion strategy. The bis-indole-N-glycosidic coupling of 6-N-(3,4-dimethoxybe
nzyl)-staurosporinone (21) with a number of highly functionalized carbohydr
ates has given access to previously unattainable, biologically relevant ana
logues.