Efficient syntheses of novel C2 '-alkylated (+/-)-K252a analogues

Authors
Tamaki, K Shotwell, JB White, RD Drutu, I Petsch, DT Nheu, TV He, H Hirokawa, Y Maruta, H Wood, JL
Citation
K. Tamaki et al., Efficient syntheses of novel C2 '-alkylated (+/-)-K252a analogues, ORG LETT, 3(11), 2001, pp. 1689-1692
Citations number
24
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
3
Issue
11
Year of publication
2001
Pages
1689 - 1692
Database
ISI
SICI code
1523-7060(20010531)3:11<1689:ESONC'>2.0.ZU;2-K
Abstract
[GRAPHICS] Recent efforts in our laboratories have resulted in a synthetic approach to ward C2'-alkylated K252a analogues via extension of a K252a cyclofuranosyla tion strategy. The bis-indole-N-glycosidic coupling of 6-N-(3,4-dimethoxybe nzyl)-staurosporinone (21) with a number of highly functionalized carbohydr ates has given access to previously unattainable, biologically relevant ana logues.