Highly enantioselective hydrogenation of (E)-beta-(acylamino)acrylates catalyzed by Rh(I)-complexes of electron-rich P-chirogenic diphosphines

Authors
Yasutake, M Gridnev, ID Higashi, N Imamoto, T
Citation
M. Yasutake et al., Highly enantioselective hydrogenation of (E)-beta-(acylamino)acrylates catalyzed by Rh(I)-complexes of electron-rich P-chirogenic diphosphines, ORG LETT, 3(11), 2001, pp. 1701-1704
Citations number
31
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
3
Issue
11
Year of publication
2001
Pages
1701 - 1704
Database
ISI
SICI code
1523-7060(20010531)3:11<1701:HEHO(C>2.0.ZU;2-Y
Abstract
Excellent enantioselectivities up to 99.7% were achieved in the hydrogenati on of (E)-beta-(acylamino)acrylates by the use of Rh(I) complexes of electr on rich diphosphines, t-Bu-BisP* and t-Bu-MiniPHOS. Low-temperature NMR exp eriments testify that monohydrides with P-carbon atom of the substrate boun d to rhodium are involved in the catalytic cycle.