Expression of inducible nitric oxide synthase in the cochlea following immune response in the endolymphatic sec of guinea pigs

Immunohistochemical study for inducible nitric oxide synthase (iNOS or NOS II) in the cochlea of guinea pigs was performed after the injection of keyh ole limpet hemocyanin (KLH) into the endolymphatic sac. Morphological chang es were observed in the cochlea of all animals after the injection of KLH, increased iNOS expression was detected in the lateral wall, organ of Corti and ganglion cells. It is known that high levels of nitric oxide can lead t o inner ear dysfunction. Our results suggest that iNOS may mediate the inne r ear disturbance as seen in endolymphatic hydrops. Copyright (C) 2001 S. K arger AG, Basel.