A variety of fatty acids can become covalently attached to platelet pr
oteins by thioester linkage, These fatty acids include palmitate, myri
state, stearate, arachidonate, and eicosapentaenoate. More than 20 pla
telet proteins can be acylated by fatty acids. Several of the acylated
platelet proteins have been identified, including glycoprotein Ib bet
a, glycoprotein IX, P-selectin, G-protein a subunits, and CD9. This re
port reviews the fatty acid acylation of platelet proteins.