Cell-matrix interactions, alteration with aging and age associated diseases. A review

Cell-matrix interactions are mediated by matrix components and cell surface receptors, among them integrins. During aging there are qualitative and qu antitative alterations of matrix components. Similar modifications were obs erved with integrins. During diseases, some integrins appear to be differen tially or ectopically expressed. Two examples are given showing the appeara nce of key receptors and the role of antagonists in their expression openin g the field of therapeutic possibilities. (C) 2001 Editions scientifiques e t medicales Elsevier SAS.