Successful pregnancy after high-dose cyclophosphamide and ifosfamide treatment in two postpubertal women

Alkylating agents, eskecially cyclophosphamide, are known to have a destruc tive effect on the ovaries and to result in sterility in many young women t reated with these drugs. This is especially true when the treatment is give n to postpubertal women. The authors describe 2 postpubertal women aged 16 and 25 suffering from Ewing sarcoma who were treated with the very aggressi ve Sloan-Kettering protocol, which includes high-dose cyclophosphamide and ifosfamide in addition to other drugs. Both women had spontaneous pregnanci es and delivered normal babies. The significance of these cases in view of the experimental various reproductive preservation measures offered to such women is discussed.