Mesomelic campomelia, polydactyly and Dandy-Walker cyst in siblings

The present report describes two fetuses, one female and one male, with thu s far undescribed skeletal malformations, The mother was a gravida 2, para 0. Both pregnancies were terminated in the second trimester because of mult iple congenital anomalies diagnosed ultrasonographically resembling a short rib-polydactyly syndrome. Both fetuses were found to have postaxial hexada ctyly of the hands and feet, marked bilateral campomelia of the forearm and shank bones, and a Dandy-Walker cyst. In addition, the fourth ventricle wa s dilated in the first sibling and the second sibling had an inverse intest inal malrotation. A literature search failed to reveal similar observations . Copyright (C) 2001 John Wiley & Sons, Ltd.