Value of p53 in the clinical management of bladder cancer.

Value of p53 in the clinical management of bladder cancer. The antioncogene p53 has been the subject of many studies in the field of bladder cancer, f or many years and there appears to be a good correlation between p53 protei n overexpression and pejorative clinicopathological factors, but contradict ory results have been reported concerning its prognostic value. These disco rdances can be partly explained by the various immunohistochemical methods used in published series. Standardization of a highly sensitive and specifi c immunohistochemical method for the detection of p53 alterations now appea rs to be essential in order to accurately determine the value of p53 in the clinical management of bladder cancer.