We investigated whether the presence of chest wall tenderness or fibromyalg
ia helped to distinguish between ischaemic and non-ischaemic chest pain. Se
venty-one patients with recurrent chest pain, 36 with normal (group A) and
35 with abnormal coronary angiograms (group B), were assessed by investigat
or-administered questionnaires, and were examined for chest wall tenderness
and fibromyalgia by a single blinded observer. Chest wall tenderness was g
reater in group A. However, it was much greater in women, who predominated
in group A, than in men, who predominated in group B, and this explained th
e intergroup difference. Seven patients (25%) (six female, one male) in the
group A and one patient (3%) (male) in group B (X-2 p=0.027) fulfilled cri
teria for fibromyalgia. Patients with recurrent chest pain are more likely
to have a ischaemic cause if they are male. Although our study suggests tha
t chest wall tenderness alone in patients with recurrent chest pain has no
value in excluding myocardial ischaemia as a cause, the confounding factor
of gender prevents our study design from answering this question conclusive
ly. Fibromyalgia is commoner in patients with chest pain and normal coronar
y angiograms, but may be related to the excess of females in this group. It
s presence does not preclude the co-existence of ischaemic heart disease.