Discrimination of small hepatic hemangiomas from hypervascular malignant tumors smaller than 3 cm with three-phase helical CT

PURPOSE: To compare the appearance of small hepatic hemangiomas at nonenhan ced acid contrast material-enhanced helical computed tomography (CT) with t hat of small (<3-cm) hypervascular malignant liver tumors and to evaluate t he accuracy of multiphase helical CT for differentiating small hemangiomas from small hypervascular malignant tumors. MATERIALS AND METHODS: Radiologists reviewed multiphase helical CT liver im ages in 86 patients with 37 hemangiomas and 49 malignant liver tumors. They evaluated lesion type and degree of enhancement for change from arterial t o portal venous phase. They rated their confidence in the discrimination of hemangiomas from malignant tumors. RESULTS: At arterial phase CT, enhancement similar to aortic enhancement wa s observed in 19%-32% of hemangiomas and 0%-2% of malignant tumors; globula r enhancement, in 62%-68% and 4%-12%, respectively. At portal venous phase CT, enhancement similar to blood pool enhancement was observed ih 43%-54% o f hemangiomas and 4%-14% of malignant tumors; globular enhancement, in 46%- 49% and 0%-2%, respectively. For all readers and all phases of enhancement, the area under the receiver operating characteristic curves was 0.81-0.87, indicating that inherent accuracy of CT is high and that there was no sign ificant difference (P > .28) in overall accuracy. Readers diagnosed hemangi omas with 47%-53% mean sensitivity with all enhancement phases and diagnose d malignant lesions with 95% mean specificity. CONCLUSION: Small hemangiomas frequently show atypical appearances at CT. T wo-phase helical CT does not improve sensitivity but does improve specifici ty for differentiating hemangiomas from hypervascular malignant tumors.