Renovascular impedance and esophageal varices in patients with Child-Pugh class A cirrhosis

PURPOSE: To evaluate the frequency of increased renovascular impedance and its relationship with the presence of esophageal varices in patients with C hild-Pugh class A cirrhosis without ascites. MATERIALS AND METHODS: The intraparenchymal renal resistive index (RI) (ref erence value, <0.7) and portal congestive index (ie, the ratio between the portal cross-sectional area and mean flow velocity; reference value, <0.07) were measured by using duplex Doppler ultrasonography in 50 consecutive pa tients. The frequency of varices was assessed endoscopically. The data were analyzed with the Fisher exact test. RESULTS: The renal RI was consistent with increased impedance (ie, >0.7) in 18 (36%) patients and was normal in 32 (64%). The proportion of patients w ith varices was significantly higher in the former group: 14 (78%) versus 1 0 (31%) (P =.002). In detection of the presence of varices, the renal RI wa s uniformly better than the portal congestive index in terms of sensitivity (58% vs 48%), specificity (84% vs 54%), and positive (3.60 vs 1.04) and ne gative (0.50 vs 0.96) likelihood ratios. RI determination improved the abil ity to exclude the presence of varices from a basal pretest probability of 52% (26 of 50 patients) to a final one of 69%, (22 of 32 patients) and that of predicting the presence of varices from 48% (24 of 50 patients) to 78% (14 of 18 patients). CONCLUSION: A substantial proportion of patients with Child-Pugh class A ci rrhosis without ascites have increased renovascular impedance; this signifi cantly correlates with the presence of varices.